A Public Lab region is a loose geography that encompasses multiple states or provinces, has its own umbrella mailing list, and may also contain local mailing lists. To reinforce diversity, regions include both rural and urban areas, and tend to ignore political boundaries.
- http://publiclab.org/wiki/northeast (contains five chapters)
- http://publiclab.org/wiki/southeast (contains two chapters)
- http://publiclab.org/wiki/midwest (contains one chapter)
- http://publiclab.org/wiki/gulf-coast (currently functioning as a single chapter)
- http://publiclab.org/wiki/norcal (currently functioning as a single chapter)
- http://publiclab.org/wiki/northwest (contains two chapters)