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Steroid Testosterone Metabolism - Steroid - Biosynthesis, Metabolism, Hormones | Britannica (Discount Code: t973DiZo)
Testosterone is the principal androgenic anabolic steroid in humans. It is produced mainly in the testis and it is involved in the development of several tissues and processes []. Testosterone metabolism helps to balance the production rate to maintain the androgen concentrations at appropriate levels []. The main site of testosterone metabolism is the liver (owing to the presence of steroid . ->
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Metabolomics of testosterone enanthate administration during severe . ->
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It has been shown that human serum participates in vitro in the metabolism of testosterone. 2. The reaction between serum proteins and testosterone is twofold: first, a reversible binding between the steroid and a protein without formation of metabolites; second, the enzymatic degradation of the steroid molecule.
Revisiting steroidogenesis and its role in immune regulation with the . ->
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Tóth M, Zakár T. Relative binding affinities of testosterone, 19-nortestosterone and their 5α-reduced derivatives to the androgen receptor and to other androgen-binding proteins: a suggested role of 5α-reductive steroid metabolism in the dissociation of "myotropic" and "androgenic" activities of 19-nortestosterone.
Testosterone Synthesis, Transport, and Metabolism | SpringerLink->
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Purpose: Sex-steroid hormones are associated with postmenopausal breast cancer but potential confounding from other biological pathways is rarely considered. We estimated risk ratios for sex-steroid hormone biomarkers in relation to postmenopausal estrogen receptor (ER)-positive breast cancer, while accounting for biomarkers from insulin/insulin-like growth factor-signaling and inflammatory .
Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review->
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Testosterone, like other lipophilic steroids secreted from steroidogenic tissues, leaves the testis by diffusing down a concentration gradient across cell membranes into the bloodstream, with smaller amounts appearing in the lymphatics and tubule fluid. . designed to bypass the avid first-pass hepatic metabolism of testosterone that is .
Testosterone metabolism. Testosterone is a steroid hormone metabolized . ->
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Toth M, Zakar T. Relative binding affinities of testosterone, 19-nortestosterone and their 5-alpha-reduced derivatives to the androgen receptor and to other androgen-binding proteins---a suggested role of 5- alpha-reductive steroid-metabolism in the dissociation of myotropic and androgenic activities of 19-nortestosterone.
Testosterone - Wikipedia->
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1 The medical and cultural history of testosterone and the testes; 2 Testosterone: biosynthesis, transport, metabolism and (non-genomic) actions; 3 Pathophysiology of the androgen receptor; 4 Methodology for measuring testosterone, dihydrotestosterone and sex hormone-binding globulin in a clinical setting; 5 The behavioral correlates of .
Anabolic-androgenic steroids: How do they work and what are the risks?->
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Testosterone is metabolized by practically every tissue in the body to a large variety of related steroids. The metabolites vary with each tissue and appear to be formed to meet the specific needs of the particular tissue and animal. The many biologic actions of testosterone do not change in parallel in the various metabolites.
Testosterone metabolism revisited: discovery of new metabolites - Springer->
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Abstract. Testosterone is the principal androgen secreted by the human testis. Testosterone is carried by the circulation to target cells, where transactivation of the androgen receptor manifests its actions as a classical steroid hormone. Alternatively, the biological activity of testosterone might be increased, decreased, or categorically .
Androgen Physiology, Pharmacology, Use and Misuse->
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To investigate steroid formation from testosterone, COS-7 cells (passages 3 to 15) were incubated with [3 H]testosterone and the radioactive metabolites were analyzed by reversed-phase HPLC.
Expression of steroidogenic enzymes and metabolism of steroids . - Nature->
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This response is apparently a result of decreased maturation of the epiphyseal plates and a decrease in long bone growth. 49 Corticosteroids depress the secretion of thyroid-stimulating hormone in patients with myxedema, 50 and reduce the physiologic effectiveness of thyroxine. 51 High doses of steroid decrease luteinizing hormone release in .
Studies in steroid metabolism. III. Metabolism of testosterone by human . ->
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Steroid 5α-reductase 2 (SRD5A2), a testosterone metabolism enzyme, is implicated in human disease. Structural and biochemical analyses of PbSRD5A, a bacterial homolog, reveal SRD5A2 substrate .
Testosterone: biosynthesis, transport, metabolism and (non-genomic . ->
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The metabolism of each steroid is shown from left to right and the structures of the major urine products are shown. 5α-dihydrotestosterone (DHT), the most potent androgen, is derived from testosterone by 5α-reduction and, thus, its formation is only reflected by urine androsterone.
Testosterone Metabolism - an overview | ScienceDirect Topics->
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Testosterone is the primary male hormone responsible for regulating sex differentiation, producing male sex characteristics, spermatogenesis, and fertility. Testosterone's effects are first seen in the fetus. During the first 6 weeks of development, the reproductive tissues of males and females are identical. At around week 7 in utero, the SRY (sex-related gene on the Y chromosome) initiates .
Studies in Steroid Metabolism: Iii. Metabolism of Testosterone by Human . ->
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Testosterone Metabolism. Male testosterone metabolism exhibits a circadian rhythm, which is higher during morning and lower at the end of the day [13]. . The liver has a primary role in metabolism, detoxification, and excretion of sex steroid hormones. Chronic hepatic failure damages the hypothalamo-hypophyseal-testicular axis, and .
Metabolites of testosterone: significance in the vital economy->
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Testosterone metabolism. Testosterone is a steroid hormone metabolized from cholesterol by desmolase activity. Pregnenolone is a product of this reaction and is converted to testosterone via .
Testosterone: an overview of biosynthesis, transport, metabolism and . ->
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Miller WL (1988) Molecular biology of steroid hormone synthesis. Endocr Rev 9: 295-318 Miautani S, Tsujimura T, Akashi S, Matsumoto K (1977) Lack of metabolism of progesterone, testosterone and pregnenolone to 5a-products in monkey and human testes compared with rodent testes. J Clin Endocrinol Metab 44: 1023-1031. Google Scholar
Physiologic and Pharmacologic Effects of Corticosteroids->
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Studies in steroid metabolism. III. Metabolism of testosterone by human serum . Studies in steroid metabolism. III. Metabolism of testosterone by human serum J Biol Chem. 1955 Apr;213(2):969-75. Authors H H WOTIZ, R RICHTERICH VAN BAERLE, H M LEMON. PMID: 14367357 No abstract available. MeSH terms .
Physiology, Testosterone - StatPearls - NCBI Bookshelf->
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Testosterone, the major androgen in men, is necessary for fetal male sexual differen-tiation, pubertal development, the maintenance of adult secondary sex characteristics, . Cholesterol metabolism and steroid-hormone production. Biochem Soc Trans 1978;6:893-898.
Pharmacology of anabolic steroids - PMC - National Center for . ->
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Testosterone is a steroid from the androstane class containing a ketone and a hydroxyl group at positions three and seventeen respectively. . In the hepatic 17-ketosteroid pathway of testosterone metabolism, testosterone is converted in the liver by 5α-reductase and 5β-reductase into 5α-DHT and the inactive 5β-DHT, respectively. .
Sex-steroid hormones and risk of postmenopausal estrogen . - PubMed->
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Human steroid 5α-reductase 2 (SRD5A2) is an integral membrane enzyme in steroid metabolism and catalyzes the reduction of testosterone to dihydrotestosterone. Mutations in the SRD5A2 gene have .
Crystal structure of steroid reductase SRD5A reveals conserved steroid . ->
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Steroid - Biosynthesis, Metabolism, Hormones: In plants and animals, steroids appear to be biosynthesized by similar reactions, beginning with acetic acid, assisted by a type of enzyme. The isoprenoid hydrocarbon called squalene, which occurs widely in nature, is thought to be the starting material from which all steroids are made. Enzymatic transformation of squalene produces lanosterol in .
Peripheral Testosterone Metabolism | SpringerLink->
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Testosterone is an endogenous regulator of B-cell survival factor BAFF. In castration, . To discover steroid biosynthesis and metabolism pathway in immune cells, profiling and quantification of .
Structure of human steroid 5α-reductase 2 with the anti-androgen drug . ->
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Androgenic steroids increased during severe energy deficit and decreased during recovery (i. e. , 5alpha-androstan-3alpha, 17beta-diol disulfate, 5alpha-androstan-3beta, 17beta-diol monosulfate (2)) in the testosterone group. . The adipose tissue metabolism: Role of testosterone and dehydroepiandrosterone. International Journal of Obesity.