February 08, 2024 07:58 / Last edited by procliculi1971 5 months ago
Conversely, SR9009-treated cells showed decreased ROS levels as compared with untreated cells for both tumor cell lines. These results support the idea proposed by Sulli et al. (2018) suggesting that excessive ROS production is not involved in the enhanced sensitivity of cancer cells to SR9009 treatment. ->
🚀🚀🚀 CLICK TO VISIT OUR ONLINE SHOP 🚀🚀🚀
<-
Previous study showed SR9009 could induce the apoptosis of cancer cells by suppressing autophagy and de novo lipogenesis through repressing fatty acid synthase . Released SASP into tissue microenvironment can cause chronic inflammation. SR9009 effectively decreased the immune cell infiltration, .
6 9 Effects of SR9009 (Stenabolic) Medically reviewed by Jonathan Ritter, PharmD, PhD (Pharmacology), Puya Yazdi, MD | Written by Veronica Tello, PhD (Chemistry) | Last updated: November 3, 2021 SR9009, also known as Stenabolic, is a synthetic drug created to study the circadian rhythm.
Here we show that SR9009 and SR9011, two different agonists of REV-ERBs are specifically lethal to cancer cells and oncogene-induced senescent (OIS) cells, including melanocytic naevi, while having no effect on viability of normal cells or tissues.
Here we show that two agonists of REV-ERBs-SR9009 and SR9011-are specifically lethal to cancer cells and oncogene-induced senescent cells, including melanocytic naevi, and have no effect on the viability of normal cells or tissues.
Stenabolic is a type of chemical known as a metabolic modulator. It changes how the body uses fat. It is banned by the World Anti-Doping Agency (WADA). Stenabolic is used for weight loss, diabetes .
SR9009 induces a REV-ERB dependent anti-small-cell lung cancer effect through inhibition of autophagy - PMC Journal List Theranostics v. 10 (10); 2020 PMC7150483 As a library, NLM provides access to scientific literature.
Recent work by Sulli and colleagues suggested that SR9009 has powerful antitumor effects on multiple cancer types, including brain cancer, leukemia, breast cancer, colon cancer and melanoma . The therapeutic effects of SR9009 on glioblastoma [ 11 ], hepatocellular carcinoma [ 12 ] and lung cancer [ 13 ] were subsequently demonstrated.
In a recent study, Sulli et al. provide evidence that pharmacological targeting of circadian clock genes could be effective as a cancer chemotherapy. Treatment of a variety of cancer cell types with SR9009 and SR9011, two small molecule agonists of REV-ERBα and REV-ERBβ, led to cancer cell death but did not affect the viability of nontransformed cells.
Research purposes Anecdotal results Safety for human consumption Summary SR9009 (Stenabolic) is an experimental drug to be used in professional laboratories. Some bodybuilders and other athletes claim its consumption helps improve weight loss and lean muscle building, but there is no evidence that it is safe for human consumption. 3
Weilin Ye Haihong Wang Show all 11 authors Abstract and Figures Rationale: The circadian clock coordinates cell proliferation and metabolism and impacts the progression of some diseases,.
REV-ERBα (nr1d1, nuclear receptor subfamily 1 group D member 1) is a transcriptional repressor that in mammals regulates nutrient metabolism, and has effects on energy homeostasis, although its role in teleosts is poorly understood. To determine REV-ERBα's involvement in fish energy balance and metabolism, we studied the effects of acute and 7-day administration of its agonist SR9009 on .
Shutterstock SR9009 (Stenabolic) Results: I Tried It For 1 Month. Here's What Happened They say SR9009 is safer than using steroids as well. But does SR9009 really work? And is it safe to.
Published: 03 October 2019 SR9009 administered for one day after myocardial ischemia-reperfusion prevents heart failure in mice by targeting the cardiac inflammasome Cristine J. Reitz, Faisal J. .
Abstract. The nuclear receptors REV-ERBα and -β link circadian rhythms and metabolism. Like other nuclear receptors, REV-ERB activity can be regulated by ligands, including naturally occurring heme. A putative ligand, SR9009, has been reported to elicit a range of beneficial effects in healthy as well as diseased animal models and cell systems.
Cardarine is a PPAR delta agonist and SR9009 is Rev-Erb alpha agonist. And even if they did function via the same pathway, that wouldn't necessarily mean both had the potential to cause cancer. Just because 2 drugs target the same receptors does not mean they will have the same side effects or even the same primary effect.
PMID: 31825658 PMCID: PMC6909277 DOI: 10. 1177/1759091419892713 Glioblastoma multiforme is the most aggressive brain tumor, and human T98G cells constitute a useful glioblastoma multiforme model to evaluate the chemotherapeutic agents.
SR9009 had a cytotoxic effect on cancer cells derived from a range of tumour types, namely brain cancer, leukaemia, breast cancer, colon cancer and melanoma (Fig. 1a, d, g, j, o).
Pharmacological activation of REV-ERB nuclear receptors, the core components of the circadian clock, has antitumor effects on various malignancies, while the impact of SR9009 on prostate cancer.
Methods. The antitumor effects of bortezomib and SR9009 were evaluated using human MM cell lines (RPMI8226 and U266) in vitro and in vivo nonobese diabetic/severe combined immunodeficient (NOD/SCID) murine xenograft MM model. The assessment of cell viability was conducted using the cell counting kit-8 (CCK8) method, whereas the measurement of cell proliferation was performed with the inclusion .
In vitro tests showed that SR9009 could be used to effectively attack other types of cancer cell, including those typical to breast cancer, colon cancer, leukemia, and melanoma, or skin cancer.
Fact Checked Written by Steve Theunissen Updated On September 16, 2022 Affiliate Disclosure Skip Ahead What is Stenabolic? Benefits of Stenabolic If you're looking for a SARM-like compound that is safe, doesn't require PCT, and boosts your energy while helping you get cut to the bone, then you need to know about Stenabolic.
SR9009 induces a REV-ERB dependent anti-small-cell lung cancer effect through inhibition of autophagy 2020 Mar 15;10 (10):4466-4480. doi: 10. 7150/thno. 42478. eCollection 2020. Weitao Shen 1 , Wei Zhang 1 , Weilin Ye 1 , Haihong Wang 2 , Qingxi Zhang 3 , Jie Shen 1 , Qingsha Hong 4 , Xiang Li 5 , Ge Wen 6 , Ting Wei 1 , Jian Zhang 1