February 07, 2024 23:28 / Last edited by puraterri1986 5 months ago
The Study of Tamoxifen and Raloxifene (STAR) is a clinical trial (a research study conducted with people) comparing the drug raloxifene (Evista(r)) with the drug tamoxifen (Nolvadex(r)) in reducing the incidence of breast cancer in postmenopausal women who are at an increased risk of developing the disease. ->
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Table 1 summarizes the results of randomized controlled trials of SERMs and AIs for the primary prevention of breast cancer. In 1998, the Breast Cancer Prevention Trial or NSABP-P1 trial demonstrated that the SERM, tamoxifen, given for 5 years reduced breast cancer incidence in high-risk women by 49% (absolute risk of 2. 48% vs. 4. 25% for .
Raloxifene - 70-80% removal, less side effects, almost no relapse chances, slightly expensive I personally have chose raloxifene to begin with and if after a certain point it stops working or I stop seeing any growth, I will be switching to Tamoxifen 20mg and will update accordingly.
Our current analysis of data from NHIS 2010 estimates that 20,598 (95% CI, 518-114,864) U. S. women were taking tamoxifen for primary chemoprevention, and 96,890 (95% CI, 41,277-192,391) U. S. women were taking raloxifene for that purpose. These prevalence estimates do not suggest an increase in chemoprevention use from 2000 through 2010.
Gynecomastia refers to an enlargement of the male breast caused by benign proliferation of the glands ducts and stromal components including fat. It is the most common form of breast swelling seen in adolescent males. During pubertal development, gynecomastia can develop as a result of transient relative imbalances between androgens and estrogens.
Article metrics Rapid responses Response Rapid Response: Treatment of gynaecomastia with raloxifene. Sir, We read with interest the Editorial on the treatment of gynaecomastia by Khan & Blamey. 1 They review the experience of several centres, including their own, with the use of tamoxifen. We would like to comment
r/gynecomastia • 2 yr. ago UniquelyDefined Positive Experiences on Tamoxifen or Raloxifene This subreddit seems to be exclusively a surgery cheerleading circle, so I want to start by saying that I've so far seen noticeable and good results on Tamoxifen. That's why I want to hear other people's positive stories about Tamoxifen or Raloxifene.
A randomized controlled trial reported in abstract form showed a lack of effect of the aromatase inhibitor anastrazole. 30 The ideal agent for treatment of gynecomastia would selectively block estrogen effect in breast tissue, as is the case with tamoxifen and raloxifene. Tamoxifen, an anti-estrogen, has traditionally been used in the treatment .
Gynecomastia is the benign proliferation of the glandular tissue in the male breast beneath the nipple (subareolar region). . Case series showed reduction in glanular tissue size after using SERMS (e. g. tamoxifen or raloxifene). Surgical correction is considered the gold standard treatment. Although similar to pharmacological interventions .
Gynecomastia is defined as benign proliferation of glandular breast tissue in men. Physiologic gynecomastia is common in newborns, adolescents, and older men. . Tamoxifen and raloxifene (Evista .
There were no significant changes from the end of the initial study period except for one tamoxifen responder who developed a recurrence of breast tenderness after six months, and one nonresponder who demonstrated an increase in breast size and a new onset of tenderness after ten months.
Raloxifene: 60mg daily for 10 days ONLY. Then 30mg daily until gynecomastia is reversed. Recommended Supplementation During Raloxifene Treatment: Vitamin D and Calcium are recommended during Raloxifene treatment. 5000 IU vitamin D daily, and 500 mg of Calcium daily. This protocol above will take time. This is not a 2 week process.
Results Mean (SD) age of treated subjects was 14. 6 (1. 5) years with gynecomastia duration of 28. 3 (16. 4) months. Mean reduction in breast nodule diameter was 2. 1 cm (95% CI 1. 7, 2. 7, P <. 0001) after treatment with tamoxifen and 2. 5 cm (95% CI 1. 7, 3. 3, P <. 0001) with raloxifene.
Raloxifene is a medication used to treat postmenopausal osteoporosis and the risk reduction of invasive breast cancer in post-menopausal women. Osteoporosis represents an increased risk for developing fractures. Raloxifene is a selective estrogen receptor modulator with an estrogen-agonistic effect on bone receptors. This activity outlines the indications, action, and contraindications of .
A careful breast examination is the first step to distinguishing true gynecomastia (enlargement of the glandular tissue) from pseudogynecomastia (excessive adipose tissue) ( figure 1 ). Additional details on the breast examination and evaluation of the patient with gynecomastia are reviewed separately.
1. Raloxifene and tamoxifen are both selective estrogen receptor modulators Raloxifene and tamoxifen belong to a group of medications called selective estrogen receptor modulators (SERMs). Certain breast cancers, called hormone receptor-positive breast cancers, use the hormone estrogen to grow.
Also this info may not just benefit guys that take SSRIs, if you google "raloxifene vs tamoxifen for gyno" everything points to ralox hands down. Hopefully good things to come. . 2 Oct 30, 2013 #10 Dr JIM Well-known Member. That's one huge leap to suggest Relafen is superior to Tamoxifen based on a few PREPUBERTAL STUDIES! .
Tamoxifen and raloxifene are drugs that can reduce the risk of breast cancer in women with a higher-than-average risk, but they also have their own risks and side effects. Learn how these drugs work, how much they lower the risk, and what to consider before taking them.
Some improvement was seen in 86% of patients receiving tamoxifen and in 91% receiving raloxifene, but a greater proportion had a significant decrease (>50%) with raloxifene (86%) than tamoxifen (41%). No side effects were seen in any patients.
Key Takeaways Raloxifene is the most effective drug for reversing gynecomastia (gyno) without surgery. Raloxifene has been observed to reverse pre-existing gyno lumps, even when other drugs like Letrozole and Nolvadex have failed.
EastEnder2019 Gyno obliterated by Raloxifene - success Hey all, It's been a while since I posted and I thought I'd provide some useful insights into what worked *for me* to eliminate my gynecomastia. My gyno came on slowly and was brought on by a combination of factors that messed with my TRT.
Raloxifene gets the same results in much longer time and almost no sides for me. Easily you need 20-30 days of 60 mg/day to see some results. Even longer to completely annihilate it. Remember, I am talking in context of steroids cycles, so those are new gynos and much easier to reverse.
Adolescence is one of the three phases in life with the highest incidence of gynecomastia (pubertal or adolescence gynecomastia), with the other two peaks being infancy and old age ( 2 ). The reported prevalence of pubertal gynecomastia (PG) is up to 70% ( 2 ).